Cradle

Cradle offers several key features:

• Generate candidates: Track round status easily, from generating candidates to uploading experimental results.
• Explore reports: Manage data and view results.
• Co-optimize properties: Optimize multiple properties such as activity, binding, stability, and expression simultaneously.
• Custom predictors (Beta): Use internally developed predictors within Cradle.
• Security: SOC 2 compliant, with SSO support for Google and Microsoft, and data privacy (data not used to train models for others).
• Zero-maintenance: Fully managed AI infrastructure with optimized GPU scaling.
• Dedicated support: Team of scientists and ML experts available for assistance.

Cradle is used for various protein engineering applications:

• Antibodies: Craft mature and developable binders that avoid unwanted immunogenicity.
• Enzymes: Accelerate specific catalytic conversions, even in challenging conditions.
• Vaccines: Stabilize antigens and hit therapeutic goals faster.
• Peptides: Get to desired efficacy while ensuring stability.

Case studies include using AI to produce vaccine adjuvants without cutting down rainforest, engineering therapeutic peptides with 50% success rate under tight multi-property constraints (5× faster), improving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round (7× faster), and rescuing a stalled IgG campaign with 10 candidates meeting potency and developability criteria in 3 rounds.

The page does not provide specific pricing information. It mentions that Cradle is a software subscription with no royalties, but details are not given. Interested users are encouraged to discuss their project with the team.